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In PD, early GSH depletion in the substantia nigra precedes dopaminergic neuron loss, suggesting that redox dysfunction may be an inciting event that leads to eventual neuronal damage ( 2 Mechanisms of redox regulation in the CNS 2.1 GSH as an antioxidant in the brain The brain, being one of the most metabolically active organs in the body, requires a large share of oxygen relative to its mass

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The core feature of ME/CFS and Long COVID is a fundamental breakdown in cellular energy production

-Catenin is a major factor in the Wnt signaling pathway (Tsai et al., 2014)

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